I am either really late or really early depending on how you view this, but here are my thoughts.
1. Once you see the bracket, comb through for the games that are automatic locks and pencil the winners into the second round.
2. Next, find the games that really seem like they can go either way. Pick a winner and make sure that they don't advance much further into the bracket.
3. Check the opening lines for first round games. When you see spreads that favor lower seeds, make a note. If you see a lower seed as a 1 or 2 point dog, make a note. These should be your upset picks. The linesmakers kow more than you, use them to your advantage.
I think point #2 is the most important. I see people struggle to pick the winner of a sweet 16 game, then they have the winner of that game going to the Final Four? That's gambling. Take the gamble out of it and put a "likely scenario" together. Makes no snse to struggle over a game and then have that pick advance further.
Anyway, those are my tips. I've had a lot of success in these too, so I hope this helps.